Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor

In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size tailored present a hyperthermia response, allowing for design which active in therapies. this work, we have designed carrier nanosystem based on Fe3O4 large heating power 4-amino-2-pentylselenoquinazoline an attached that exhibits oxidative properties high selectivity against variety cancer malignant cells. For propose, two samples composed homogeneous (NPs) sizes, shapes, magnetic synthesised characterised. The surface modification prepared developed using copolymers poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol 4-amino-2-pentylselenoquinazoline. obtained nanosystems were properly Their vitro efficacy colon cells inductors was analysed, thereby leaving door open potential application multimodal agents.